Anxiety Home > Paxil and Premature Ejaculation

Paxil is known to cause sexual side effects, including delayed ejaculation. These side effects are usually undesired, but in the case of Paxil and premature ejaculation, these side effects can actually be helpful to some men. Using Paxil to treat premature ejaculation is known as an "off-label" use of the drug.

Paxil and Premature Ejaculation: An Overview

Paxil® (paroxetine hydrochloride) is a prescription medication that is licensed to treat the following conditions:
However, Paxil is sometimes used to treat premature ejaculation, although it is not approved for this use. This is known as an "off-label" use of the medication.

How Does Paxil Work for Premature Ejaculation?

It is not entirely clear how Paxil works for premature ejaculation. Premature ejaculation occurs when a man uncontrollably ejaculates too soon (either before or just after sexual penetration). As with other similar antidepressants, Paxil is known to cause sexual side effects, including delayed ejaculation. While these sexual side effects are usually undesired, in the case of men with premature ejaculation, these side effects can help to delay ejaculation.
When Paxil is used for premature ejaculation, this is considered an off-label use of the drug. The term "off-label" refers to when a prescription medicine is used to treat a disease or condition that it has not been approved by the U.S. Food and Drug Administration (FDA) to treat. Although the FDA regulates how a medication can be advertised or promoted by the manufacturer, these regulations do not restrict a healthcare provider's ability to prescribe the medication for different conditions, in different doses, or for different lengths of time. Your healthcare provider will prescribe a medicine for off-label use when he or she feels that the medication is appropriate for your situation.
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Last reviewed by: Kristi Monson, PharmD;
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