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The recommended starting dose of Sarafem for women with premenstrual dysphoric disorder is 20 mg once daily. This can be taken every single day, or it can be taken during the last two weeks of your menstrual cycle. If necessary, your healthcare provider can increase your dosage up to 60 mg once a day.

An Introduction to Dosing With Sarafem

The dose of Sarafem® (fluoxetine hydrochloride) your healthcare provider prescribes will vary, depending on a number of factors, including:
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Sarafem Dosage for PMDD

There are two options for Sarafem dosing for premenstrual dysphoric disorder (PMDD). The medication can be taken every single day, or it can be taken just during the last two weeks of your menstrual cycle (two weeks before you expect your period).
Either way, the recommended starting dose of Sarafem for treating PMDD is 20 mg once daily. Your healthcare provider may increase this amount up to Sarafem 60 mg once a day if necessary.
A lower Sarafem dosage may be recommended for women with liver problems, such as cirrhosis or hepatitis.

General Information on Taking Sarafem

Some considerations to keep in mind during treatment with Sarafem include the following:
  • If Sarafem makes you drowsy, try taking it before bedtime. If the medication causes insomnia, try taking your dosage in the morning.
  • You can take Sarafem with or without food. If the medicine bothers your stomach, try taking it with food.
  • Your dose of Sarafem should be taken at the same time each day to maintain an even level in your blood.
  • For Sarafem to work properly, you have to take it as prescribed. This medication will not work if you take it differently than how your healthcare provider recommends.
  • If you are unsure about anything related to dosing with Sarafem, please talk to your doctor, nurse, or pharmacist. Do not stop taking this drug without first discussing it with your healthcare provider.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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