Anxiety Home > Combining Sarafem With Other Medicines

Certain Seizure Medications
Taking Sarafem with certain seizure medications (carbamazepine and phenytoin) can increase the level of the seizure medication in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of the seizure medication.
 
Diazepam (Valium)
Taking Sarafem with diazepam can increase the level of diazepam in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of diazepam.
 
Digoxin (Digitek, Lanoxin)
Taking Sarafem and digoxin together can increase your risk of digoxin side effects. Your healthcare provider may need to adjust your digoxin dose when starting or stopping Sarafem.
 
Fentanyl
Taking Sarafem with fentanyl can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Intravenous Methylene Blue
Taking Sarafem with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Linezolid (Zyvox)
Taking Sarafem with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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