Drug Interactions With Paroxetine Controlled Release

Paroxetine Controlled Release Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when paroxetine controlled release is combined with any of the drugs listed above.

Alcohol

It is not recommended that you drink alcohol while taking paroxetine controlled release. Combining alcohol and paroxetine controlled release may cause unwanted side effects (see Alcohol and Paxil CR).

Aspirin

Taking paroxetine controlled release and aspirin together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking aspirin and paroxetine controlled release together.

Atomoxetine (Strattera)

Paroxetine controlled release can raise the level of atomoxetine in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to lower your atomoxetine dosage.

Certain Arrhythmia Medications

Taking paroxetine controlled release with certain arrhythmia medications can raise the levels of paroxetine controlled release or the arrhythmia medication in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.

Certain Seizure Medications

Certain seizure medications (phenobarbital and phenytoin) may decrease the level of paroxetine controlled release in your blood, perhaps making it less effective. Also, taking these two medications together can lead to increased drowsiness. If you are taking these drugs together, your healthcare provider may need to adjust your doses of them.