Medicines That Interfere With Paroxetine Controlled Release

Buspirone (BuSpar)

Because combining paroxetine controlled release with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.

 

Certain Arrhythmia Medications

Taking paroxetine controlled release with certain arrhythmia medications can raise the levels of paroxetine controlled release or the arrhythmia medication in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.

 

Certain Seizure Medications

Certain seizure medications (phenobarbital and phenytoin) may decrease the level of paroxetine controlled release in your blood, perhaps making it less effective. Also, taking these two medications together can lead to increased drowsiness. If you are taking these drugs together, your healthcare provider may need to adjust your doses of them.

 

Cimetidine (Tagamet)

Taking cimetidine with paroxetine controlled release can raise the level of paroxetine controlled release in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to lower your paroxetine controlled release dose or suggest an alternative to cimetidine.

 

Digoxin (Digitek, Lanoxin)

Taking paroxetine controlled release and digoxin together may decrease the level of digoxin in your blood. If you are taking these drugs together, your healthcare provider may need to adjust your digoxin dose when you are starting or stopping paroxetine controlled release.

 

Fentanyl

Combining paroxetine controlled release with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
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Paroxetine CR

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