Additional Drugs That React With Paroxetine Controlled Release

Intravenous Methylene Blue

Taking paroxetine controlled release with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.

 

Linezolid (Zyvox)

Taking paroxetine controlled release with linezolid can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of the symptoms mentioned above, as serotonin syndrome can be very dangerous.

 

Lithium (Eskalith, Lithobid)

Taking paroxetine controlled release with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.

 

Miscellaneous Antidepressants
Combining paroxetine controlled release with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  

Monoamine Oxidase Inhibitors (MAOIs)

Taking paroxetine controlled release and an MAOI together can cause life-threatening side effects. Never take an MAOI and paroxetine controlled release at the same time, and do not take paroxetine controlled release if you have taken an MAOI within the past 14 days (for most MAOIs). Also, because paroxetine controlled release stays in your system for so long, do not take an MAOI if you have taken paroxetine controlled release within the past five weeks (for most MAOIs).

 

If a person taking paroxetine CR needs to be on linezolid or methylene blue and there are no acceptable alternatives, then paroxetine CR should be stopped right away. The individual should be very closely monitored. Paroxetine CR may be resumed 24 hours after the last dose of linezolid or methylene blue.
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Paroxetine CR

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