Drug Combinations With Paroxetine Controlled Release to Avoid

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Taking paroxetine controlled release and NSAIDs together can increase your risk of stomach bleeding. Talk with your healthcare provider before taking NSAIDs and paroxetine controlled release together.

 

Phenothiazines

Paroxetine controlled release can raise the level of phenothiazine medications in your blood, increasing your risk of side effects. Also, taking these medications can increase your chance of drowsiness. Talk with your healthcare provider before taking these medications together.

 

One particular phenothiazine, thioridazine (Mellaril), should generally not be taken in combination with paroxetine controlled release, due to the risk of a dangerous irregular heart rhythm called QT prolongation.

 

Pimozide (Orap)

Pimozide and paroxetine controlled release should not be taken together, as the combination may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation.

 

Procyclidine (Kemadrin)

Paroxetine controlled release can raise the level of procyclidine in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your procyclidine dosage.

 

Risperidone (Risperdal)

Paroxetine controlled release can raise the level of risperidone in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your risperidone dose.

 

SSRI or SNRI Antidepressants

Taking paroxetine controlled release with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.

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