Learning More About Interactions With Paroxetine Controlled Release

St. John's Wort

Taking paroxetine controlled release with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.

 

Tamoxifen
Tamoxifen must be activated in the liver before it can work in the body. Paroxetine controlled release can inhibit this activation, perhaps making tamoxifen less effective. Check with your healthcare provider before taking tamoxifen with paroxetine controlled release.

 

Theophylline

Paroxetine controlled release may raise the level of theophylline in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to check the level of theophylline in your blood and lower your theophylline dose.

 

Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)

Taking paroxetine controlled release with tramadol can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.

 

Tricyclic Antidepressants

Taking paroxetine controlled release with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. If you are taking paroxetine controlled release with a tricyclic antidepressant, your healthcare provider may need to reduce your dose of the tricyclic antidepressant.

 

Triptans

Taking paroxetine controlled release with a triptan can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.

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