Drug Combinations With Paxil to Avoid

Certain Arrhythmia Medications
Taking Paxil with certain arrhythmia medications can increase the level of Paxil or the arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
 
Certain Seizure Medications
Certain seizure medications (phenobarbital and phenytoin) may decrease the level of Paxil in your blood, perhaps making it less effective. Also, taking Paxil with these medications can lead to increased drowsiness. Your healthcare provider may need to adjust your dose of these medications.
 
Cimetidine (Tagamet)
Taking cimetidine with Paxil can increase the level of Paxil in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your Paxil dose or may suggest an alternative to cimetidine.
 
Digoxin (Digitek, Lanoxin)
Taking Paxil and digoxin together may decrease the level of digoxin in your blood. Your healthcare provider may need to adjust your digoxin dose when you are starting or stopping Paxil.
 
Fentanyl
Taking Paxil with fentanyl can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together, and contact him or her right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Intravenous Methylene Blue
Taking Paxil with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Linezolid (Zyvox)
Taking Paxil with linezolid can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of the symptoms mentioned above, as serotonin syndrome can be very dangerous.
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Paxil Information

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