Paxil Drug Interactions

In the case of Paxil, drug interactions may occur when the medication is taken with medicines such as lithium, warfarin, or aspirin. Some Paxil drug interactions can lead to problems such as stomach bleeding, increased drowsiness, or a very dangerous combination of symptoms called serotonin syndrome. Other drug interactions involving Paxil may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation.

 

Paxil Drug Interactions: An Introduction

 
Paxil® (paroxetine hydrochloride) can potentially interact with a number of medicines. Some of the drugs that can lead to Paxil interactions include:
 

o Isocarboxazid (Marplan®)

o Phenelzine (Nardil®)

o Rasagiline (Azilect®)

o Selegiline (Eldepryl®, Emsam®, Zelapar®)

o Tranylcypromine (Parnate®)

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Ibuprofen (Motrin®, Advil®)
o Diclofenac (Cataflam®, Voltaren®)
o Ketoprofen (Orudis®)
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
  • Tryptophan
  • Warfarin (Coumadin®, Jantoven®).
     
(Paxil Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;