SNRIs (serotonin-norepinephrine reuptake inhibitors) act on specific chemicals within the brain known as serotonin and norepinephrine. Serotonin and norepinephrine are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release serotonin or norepinephrine. The serotonin or norepinephrine enters the gap between the first nerve cell and the one next to it. When enough serotonin or norepinephrine reaches the second nerve cell, it activates receptors on the cell and the message continues on its way. The first cell then quickly absorbs any serotonin or norepinephrine that remains in the gap between cells. This is called "reuptake."
Normally, this process works without any problems. When the levels of serotonin or norepinephrine become unbalanced, however, it can cause a variety of conditions, including
depression. SNRIs help to block the reuptake of serotonin and norepinephrine so more remains in the space between the brain's nerve cells. This gives the serotonin and norepinephrine a better chance of activating the receptors on the next nerve cell.
SNRIs: When and How Do I Take Them?
Some general considerations for when and how to take SNRI medications include:
- SNRIs are taken by mouth, usually one to three times per day, depending on the specific SNRI.
- If your SNRI makes you drowsy, try taking it at night. If you experience insomnia due to your SNRI, try taking in the morning.
- In general, it is usually best to take SNRIs with food.
- SNRIs should be taken at the same time(s) each day to maintain an even level of the drug in your blood.
- For SNRIs to work properly, they must be taken as prescribed. The medicataion will not work if you stop taking it.
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