Products That Can React With Sertraline

Sertraline and Serotonin Syndrome

Several of the known interactions with sertraline are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

More Detail on Interactions With Sertraline

The following sections explain in detail the potentially negative interactions that can occur when sertraline is combined with any of the drugs listed above.
According to the sertraline prescribing information, drinking alcohol while taking the medication is not recommended. Drinking alcohol while taking sertraline may cause unwanted side effects (see Alcohol and Zoloft).
Taking sertraline and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking aspirin and sertraline together.
Buspirone (BuSpar)
Because combining sertraline with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
Certain Arrhythmia Medications
Taking sertraline with certain arrhythmia medications can increase the level of arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
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Sertraline Hydrochloride

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