More Detail on Interactions With Sertraline
The following sections explain in detail the potentially negative interactions that can occur when
sertraline is combined with any of the drugs listed above.
Alcohol
According to the sertraline prescribing information, drinking alcohol while taking the medication is not recommended. Drinking alcohol while taking sertraline may cause unwanted side effects
(see Alcohol and Zoloft).
Aspirin
Taking sertraline and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking aspirin and sertraline together.
Certain Arrhythmia Medications
Taking sertraline with certain arrhythmia medications can increase the level of arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
Cimetidine (Tagamet)
Taking
cimetidine with sertraline can increase the level of sertraline in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your sertraline dose or may suggest an alternative to cimetidine.
Digoxin (Digitek, Lanoxin)
Taking sertraline and
digoxin together may increase your risk of having side effects with either drug. Your healthcare provider may need to adjust your dose of these medications.
Disulfiram (Antabuse)
You should not take sertraline oral concentrate (the liquid version of sertraline) while taking disulfiram. Because sertraline oral concentrate contains 12 percent alcohol, taking it with disulfiram will cause severe side effects.
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