Drug Combinations With Sertraline to Avoid

Cimetidine (Tagamet)
Taking cimetidine with sertraline can increase the level of sertraline in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your sertraline dose or may suggest an alternative to cimetidine.
Digoxin (Digitek, Lanoxin)
Taking sertraline and digoxin together may increase your risk of having side effects with either drug. Your healthcare provider may need to adjust your dose of these medications.
Disulfiram (Antabuse)
You should not take sertraline oral concentrate (the liquid version of sertraline) while taking disulfiram. Because sertraline oral concentrate contains 12 percent alcohol, taking it with disulfiram will cause severe side effects.
Combining sertraline with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
Intravenous Methylene Blue
Taking sertraline with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
Linezolid (Zyvox)
Taking sertraline with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms may include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Talk to your healthcare provider before taking sertraline and a linezolid. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
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Sertraline Hydrochloride

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