Drug Interactions With Sertraline

Drug interactions with sertraline hydrochloride may occur with a variety of medications. Some drugs that may interact with sertraline include aspirin, ibuprofen, and warfarin. Several potential drug interactions with sertraline can cause symptoms of serotonin syndrome, which can be very dangerous. Alcohol may also interact with sertraline.

Drug Interactions With Sertraline: An Introduction

 Sertraline hydrochloride (Zoloft®) potentially has a number of other medicines with which it may interact. Some of these drug interactions with sertraline can involve:
 
  • Alcohol
  • Aspirin
  • Certain arrhythmia medications, including propafenone (Rythmol®), flecainide (Tambocor®), and quinidine.
  • Cimetidine (Tagamet®)
  • Digoxin (Digitek®, Lanoxin®)
  • Disulfiram (Antabuse®)
  • Linezolid (Zyvox®)
  • Lithium (Eskalith®, Lithobid®)
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

  • Pimozide (Orap®)
  • Other SSRI or SNRI medications, such as:

 

 

 

 

 

 

 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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