Taking an
antidepressant (such as Wellbutrin) in combination with Xanax can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Additionally, many antidepressants can raise the level of Xanax in your blood, which further increases your risk of developing side effects.
Make sure to talk with your healthcare provider before taking Xanax with an antidepressant, as you may need to be monitored more closely and may need a lower Xanax dose.
(Click Xanax Drug Interactions for more information on this topic, including a list of other medications that may interact with Xanax.)