Xanax Drug Interactions

If you combine alcohol, sleep medications, or antidepressants with Xanax, drug interactions may potentially occur. Drug interactions with Xanax can raise your risk of side effects and increase the level of Xanax in your blood. To reduce the risk of developing Xanax drug interactions, you should make sure to talk with your healthcare provider about any interactions that may apply to you.

An Overview of Xanax Drug Interactions

Xanax® (alprazolam) can potentially interact with several other medications. Some of these medicines that may lead to Xanax interactions include:



  • Barbiturates, including:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Certain antibiotics or antifungals, including:





  • Protease inhibitors, such as:



  • Seizure medications
  • Sleep medications.
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Xanax Drug Information

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